IME no. I've had 3 CBB and none of them did anything with Aiptasia. If you can remove the Melanurus Wrasse, try some Berhiga Nudis....I've tried everything and never had luck...After adding about 30 Berhia Nudis to my 270G system I'm seeing them disappear, I'm also seeing them out at night when I've been checking things out with a flashlight after lights out. Yes, it was an expensive investment, but this way I'm not having to nuke my tank and start over. I had Aiptasia in places where I have no idea how a CBB or Filefish would reach... In the month I've had them I've noticed the Aiptasia population be cut back by about 1/3rd if not more! The only way I could see Aiptasia being prevented is to QT everything going into your tank that is wet. I've seen these things attached to frags, snails, hermits, and I'm pretty sure at some point my Foxface had a little baby Aiptasia stuck to his side too!