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If you add bracing, yes.
The trim is actually a brace, not only do you compromise the integrity of the tank in removing it, you will most likely find the edges to be very rough/sharp, they skip on the glass edge polishing when trim is used.
I've done a 20G long but not a tall. The edges will be sharp but I used sandpaper to dull them. A new tank will be easier to do bc the silicone will be a little more flexible. Razor blades and rubbing alcohol will help take off the silicone residue. I did not take off the bottom rim bc I didn't think it would add that much to the aesthetics.
I removed the top trim on my 20H because it was sitting in my buddies yard upside down with dirt all mashed into it. Just used a nice sharp straight razor to cut the plastic trim in the corners, then ran the razor along the glass under the trim in successively deeper passes. Came off like a charm. I then used said razor to scrape the silicone off. Of course, I ended up ditching the tank because it failed the water test along one of the bottom seams. -_-
So yes, it can be done, without breaking the glass. But, I don't think I would have used it anyways because it bowed a fair amount without the top trim on it.