Fluconazole: Questionable ingredients?

[NickHolmes]

I've had good results dosing fluconazole but it usually starts reappearing in the same spots a year later. I purchased a different brand from what I've used before but it has these inactive ingredients that the others didn't have.

MICROCRYSTALLINE CELLULOSE
ANHYDROUS DIBASIC CALCIUM PHOSPHATE
POVIDONE K30
CROSCARMELLOSE SODIUM
FD&C RED NO. 40
MAGNESIUM STEARATE

With limited knowledge, calcium phosphate is a concern but I'm not sure about the others. No luck googling either.

 

[Randy Holmes-Farley]

None of those seem a significant concern to me at the levels you'd encounter. Most will settle out since they will not be soluble, so if you make a solution and dose just the clear fluid, you'd avoid most of them anyway.

 

[NickHolmes]

Thank you Randy

 

[NickHolmes]

None of those seem a significant concern to me at the levels you'd encounter. Most will settle out since they will not be soluble, so if you make a solution and dose just the clear fluid, you'd avoid most of them anyway.

Is there a reason why some manufacturers would add these and not others?

 

[Dburr1014]

I've had good results dosing fluconazole but it usually starts reappearing in the same spots a year later. I purchased a different brand from what I've used before but it has these inactive ingredients that the others didn't have.

MICROCRYSTALLINE CELLULOSE
ANHYDROUS DIBASIC CALCIUM PHOSPHATE
POVIDONE K30
CROSCARMELLOSE SODIUM
FD&C RED NO. 40
MAGNESIUM STEARATE

With limited knowledge, calcium phosphate is a concern but I'm not sure about the others. No luck googling either.

Your OP didn't say why you are dosing this in the first place. Can I ask why and what is showing up??

Edit: for GHA?

 

[Randy Holmes-Farley]

Is there a reason why some manufacturers would add these and not others?

Presumably these are tablets or capsules?

Such formulation ingredients generally need to be added to make the materials flow into the molds and hold together as a tablet after molding.

Any tablets you take will have such ingredients. It's a big job of drug development people to find what works best given the nature of the drug, etc.

The color is likely there to help patients recognize the tablets compared to others they may take to be sure they are taking the right thing. Taking the wrong medicine is a substantial problem when people take 5 or 10 different meds a day.

 

[Randy Holmes-Farley]

FWIW, I expect all tablets have some of these sorts of formulation ingredients and ones that don't list them are either powders in a packet, or just do not mention them but still have them.

 

[NickHolmes]

Your OP didn't say why you are dosing this in the first place. Can I ask why and what is showing up??

Edit: for GHA?

That would help.. Bryopsis

 

[NickHolmes]

Presumably these are tablets or capsules?

Such formulation ingredients generally need to be added to make the materials flow into the molds and hold together as a tablet after molding.

Any tablets you take will have such ingredients. It's a big job of drug development people to find what works best given the nature of the drug, etc.

The color is likely there to help patients recognize the tablets compared to others they may take to be sure they are taking the right thing. Taking the wrong medicine is a substantial problem when people take 5 or 10 different meds a day.

Thanks. Pharmaceuticals are heavily regulated in South Africa so I thought each ingredient would be clearly stated with the other brands

 

[NickHolmes]

FWIW, I expect all tablets have some of these sorts of formulation ingredients and ones that don't list them are either powders in a packet, or just do not mention them but still have the

Presumably these are tablets or capsules?

Such formulation ingredients generally need to be added to make the materials flow into the molds and hold together as a tablet after molding.

Any tablets you take will have such ingredients. It's a big job of drug development people to find what works best given the nature of the drug, etc.

The color is likely there to help patients recognize the tablets compared to others they may take to be sure they are taking the right thing. Taking the wrong medicine is a substantial problem when people take 5 or 10 different meds a

A small group here had very bad results, could any of these ingredients have contributed to this?

 

[NickHolmes]

FWIW, I expect all tablets have some of these sorts of formulation ingredients and ones that don't list them are either powders in a packet, or just do not mention them but still have them.

They’re capsules

 

[PharmrJohn]

I'm a Pharmacist by trade. All capsules and tablets have an inactive ingredient set that is not pronouncable at best. Some of these are added as binding agents, while others are added to make medications unpalatable to kids looking for their parents' 'candy'. Some are added to MASK bitter taste. Coloring agents are added as part of an identification scheme (as well as tablet imprints). Yet other meds are combined with agents that allow 'activation' when they hit the liver (called a prodrug). As stated above even powders have inactive ingredients. And, also of great importance, some of these hidden ingredients will extend the expiration date to something more acceptable in the industry
(on the order of years rather than months, days or even hours). No way around it folks!

 

[Randy Holmes-Farley]

A small group here had very bad results, could any of these ingredients have contributed to this?

I think that is very unlikely.

What was the bad result?

 

[NickHolmes]

I think that is very unlikely.

What was the bad result?

I didn’t read the entire thread but saw a couple posts about killing sps colonies, snails etc. I’ve used it a few times with zero problems but the listed ingredients on this brand caught my eye

 

[NickHolmes]

I'm a Pharmacist by trade. All capsules and tablets have an inactive ingredient set that is not pronouncable at best. Some of these are added as binding agents, while others are added to make medications unpalatable to kids looking for their parents' 'candy'. Some are added to MASK bitter taste. Coloring agents are added as part of an identification scheme (as well as tablet imprints). Yet other meds are combined with agents that allow 'activation' when they hit the liver (called a prodrug). As stated above even powders have inactive ingredients. And, also of great importance, some of these hidden ingredients will extend the expiration date to something more acceptable in the industry
(on the order of years rather than months, days or even hours). No way around it folks!

Thanks for the info