My setup is about 300 gallons total water volume. Tank is 250 gallon, sump is 80 gallon, except for red slime either cyano or spirulina or both, everything is doing well. The cyano started about 2 months ago but was not overtaking anything. Don't know if it was caused by a very old bag of salt I had or some other change in the water.
I pulled some mat out of my tank, put it into about six oz. of tank water with 1 ml of peroxide, water stared turning pink in less than two hours. Dosed 1 ml peroxide per 10 gallons twice a day and it does not appear to make a difference after 7 days of dosing. The peroxide did not appear to hurt anything not even peppermint shrimp, did cause zoas to close for about an hour. Vibrant seemed to make it worse. I made a few changes to my system and waiting to see if they help. Was using all in one bio pellets which do seem to keep po4 and no3 undetectable but got tired of cleaning and feel it actually made my tank dirtier looking. Went back to GFO in a reactor and put on a sulfur reactor, I have also added a chaeto reactor. I have a bare bottom lots of water flow and using Orphek Atlantic LED fixtures. I don't have a cleanup crew which I thought about adding. I also don't do frequent water changes, I have done 2 at 10% in almost 1 1/2 years. I do have to make up 3-4 gallons of mixed water a week to make up for what I remove with my skimmer. I am waiting to see if my changes help before I do anything other treatments. I will wait about a month and if it does not help will try either Boyds Chemi-Clean or Ultralife red slime remover.