I picked up something orange that fell out of my live rock onto the floor without gloves and added it to my tank. It felt like something stung me. I immediately went to wash my hands and put on some nitrile gloves to add the rest of my shipment of live rock. I discovered it later and it ended up being a starfish. I will wear gloves whenever I touch anything in my tank from now on.
Definitely wear gloves handling rock. Bristleworm pokes are especially crappy.