Yes, my Lagoon 100 is acrylic and I've had two 55 gallon acrylics.
@TheWB has a tank nearly identical to mine that is also acrylic.
Quick response, good quality acrylics don't yellow. They can scratch but truthfully I don't think there is a big difference between a quality acrylic and a low-iron glass tank as far as scratch resistance. Also acrylics seem to hide their scratches a little better. The real key is a good fabricator that uses quality acrylics. A quality acrylic also shouldn't craze. Besides that many scratches can be sanded out which isn't possible with a glass tank.
I've only retired one tank due to scratches, a 15 gallon Waterbox low-iron glass tank. I would say that you want to use a reputable acrylic fabricator for an acrylic tank as a few of the mass-market acrylic tanks are not as well made as they could be.
Cleaning is a little different as you use plastic-edged scrappers, melamine sponges (like magic erasers), and acrylic safe pads/cleaners instead of the stuff you are used to. I'd say it's a little more work if you let things go but it isn't much harder.
