i've been using CS CIE for nearly a year on my friend's recommendation(asian edition , not joker coral edition). my experience is that it effectively prevents brown jelly disease, and it works remarkably well on corals in the early stages of decay, especially effective on torch, goni and mushroom. compared it to Ciprofloxacin and KFC, and CIE indeed has a higher efficacy rate. It seems to have an effect on flatworms. I've been dosing one bottle monthly as routine maintenance, and gradually, the flatworms have completely disappeared.