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Suppose that you have, say, a run of 1-inch diameter pipe running from a pump to something. Suppose you then replaced 90% of the pipe with say 1.25-inch pipe but the tied into the last 10% with a reduction fitting. Would having 90% of the run increase pressure or would that last 10% ruin things for the entire run? What if that last 10% were just an adapter (1%?)?
