New to a reef system, have always used bare hands in my planted tank. That said, infections are a real issue. A man I used to fish with spent a month in the hospital (a good part of that in ICU) due to an infection he got while baiting a hook - almost lost his arm (the "flesh eating bacteria"). I lucked out with my anaerobic infection. Got to the Dr and my BP was 70/50, but the drugs he gave me worked well and fairly quickly - was fine in 2 days. Best friend from grade school spent a week or two in the hospital with his anaerobic infection. While I can only guess what cause our 2 infections - pretty sure it was working around livestock.
For me I was working in a chicken coop, then later that day took a fall and bruised my shin. Next day my boots rubbed on the bruise. Was barely conscious day 3. I always suspected it was a combination of the dirty pants and the hard strike on my shin - but it is possible the rub of the boots is what broke the skin barrier.