I have a question about dosing Cipro

[Randy Holmes-Farley Verified Community Expert]

https://pubmed.ncbi.nlm.nih.gov/2081719/​

Solutions of ciprofloxacin were irradiated with different wavebands of ultraviolet and visible radiation and the antibiotic activity of the drug was determined against Escherichia coli. A wavelength dependent loss of antibiotic activity was found with maximal effect around 320 nm; no effect occurred with visible irradiation. The degree of the decrease in activity with longer wavelength ultraviolet (UVA) radiation was sufficient to indicate that human exposure to sunlight through window glass (greater than 320 nm) or UVA from tanning sunbeds may result in a significant reduction in both cutaneous and circulating levels of ciprofloxacin.

 

[reefmaster70]

"Ciprofloxacin is highly photosensitive and breaks down under ultraviolet (UV) and near-UV radiation. While its absolute peak absorption occurs in the deep UV spectrum (around 270–280 nm), it remains highly photolabile under UVA and near-visible violet wavelengths (320–420 nm). Modern reef aquarium LED fixtures intentionally output a heavy concentration of these exact violet (410–420 nm) and near-UV (380–400 nm) wavelengths to stimulate coral fluorescence." (Royal Society of Chemistry)

 

[Randy Holmes-Farley Verified Community Expert]

"Ciprofloxacin is highly photosensitive and breaks down under ultraviolet (UV) and near-UV radiation. While its absolute peak absorption occurs in the deep UV spectrum (around 270–280 nm), it remains highly photolabile under UVA and near-visible violet wavelengths (320–420 nm). Modern reef aquarium LED fixtures intentionally output a heavy concentration of these exact violet (410–420 nm) and near-UV (380–400 nm) wavelengths to stimulate coral fluorescence." (Royal Society of Chemistry)

Link?

I show the paper with the actual data. There is very little degradation at reef tank wavelengths.

 

[JGT]

Interesting… The link to the study provided by @RSNJReef does indicate that while not as drastic as UV lighting, what they call “indoor fluorescent lighting” does degrade Cipro.

 

[Randy Holmes-Farley Verified Community Expert]

Interesting… The link to the study provided by @RSNJReef does indicate that while not as drastic as UV lighting, what they call “indoor fluorescent lighting” does degrade Cipro.

The paper I posted shows zero degradation when irradiated at 400 or 430 nm, but is degraded by 365 nm and shorter wavelengths.