I suppose you give all of these medicines prior it got blind. I have a totally different possible explanation for the blindness. You do not see with your eyes - you see with your brain. Among non-migration fish species - the part of the body that contain most fat and have the fastest turnover of fat is the brain. Most of the medicines you mentioned is lipophilic and will bioaccumulate in the fat deposits of the fish (or/and their metabolites) Fat is the primary energy source for most fish species and the fat deposits will be filled or emptied depended off energy intake and energy output. It means that once in the fish – these drugs will be accumulated from and released into the bloodstream in higher and higher levels if they still are in the water (bath) or taken orally. Saltwater fish does drink – it means that these lipophilic drugs have two pathways into the fish. Through gills, body and orally by the water they drink. The excretion rate of these lipophilic drugs (or their metabolites) is normally low in SW fish. Normally is the pathway through the urine – but SW fish pee very little because of osmotic issues (the same reason why they drink water) IMO – this could be an equally good explanation as that the blindness is caused by an unknown microorganism.
The “blindness” occurred some time after being removed from medications... not right away. I do see your point though, I’ve heard of prolonged copper exposure causing blindness, which is why I asked about the copper exposure. It doesn’t seem outside the normal range though.
OP... can you give a short-list... each medication you’ve used and length of treatment? If it is a side-effect of one of the medications used... I’d like to get a better idea of what may have been the cause. Since many other fish have undergone the same treatments, and have not gone blind or been negatively impacted otherwise.
The lack of feeding response is concerning... a fish that is “blind” might not see the food as easily, but they wouldn’t ignore food being held right in front of their nose.