I find the 225 micron Red Sea mesh socks are very easy to maintain - just rinse and turn inside out under running water. I used the two that came with my tank (RSR 250) for the first year and have now bought a spare pair and also a 100 micron pair of socks. At the moment I am running the mesh and cleaning every 2nd day as I am clearing up a GHA issue. I swap the clean pair for the dirty, rinse and clean the dirty and hang them outside under shelter to dry. Repeat every 2-3 days.
Once the tank starts running clean I will try swapping in the 100 micron socks to polish the water. If that works then I will simply swap the mesh back in when I want to clean the socks (expect weekly), rinse and bleach the socks and then swap them back in a day or so later. When we go away I will simply go back to the mesh for convenience of the house sitter.