Study: Praziquantel degradation in marine aquarium water

[midwestE]

After reading over a post on treating flukes with prazi, I did some research and found this study:

https://peerj.com/articles/1857/

It seems to indicate the first round of prazi degraded to undetectable levels in 9 days and subsequent treatments to the same tank degraded in 2 +/- 1 day due to microbial consumption.

This makes me wonder, when treating the hatching eggs per the calculator at http://marineparasites.com/paratreatmentcal.html

should the second dose be followed by a third dose 2 days or one day after? based on both the above, could this be the reason that API suggeste the second dose after 48 hours?

@Humblefish

 

[EmdeReef]

After reading over a post on treating flukes with prazi, I did some research and found this study:

https://peerj.com/articles/1857/

It seems to indicate the first round of prazi degraded to undetectable levels in 9 days and subsequent treatments to the same tank degraded in 2 +/- 1 day due to microbial consumption.

This makes me wonder, when treating the hatching eggs per the calculator at http://marineparasites.com/paratreatmentcal.html

should the second dose be followed by a third dose 2 days or one day after? based on both the above, could this be the reason that API suggeste the second dose after 48 hours?

@Humblefish

The secons dose is more of a precaution to ensure full eradication.

 

[midwestE]

The secons dose is more of a precaution to ensure full eradication.

With the fast degredation, I would assume the timing of the second dose needs to be pretty exact. I've heard references to 5-7 days but at 5 days, if the prazi degraded to undetectable in two days, if any hatched at 7 days, they would be free and clear to reinfect

 

[jsvand5]

With the fast degredation, I would assume the timing of the second dose needs to be pretty exact. I've heard references to 5-7 days but at 5 days, if the prazi degraded to undetectable in two days, if any hatched at 7 days, they would be free and clear to reinfect

But I think you are trying to kill the newly hatched flukes before they have time to reproduce with the second dose. From what I have read, prazi is supposed to kill the flukes within 24hrs. You don’t need the prazi to be at therapeutic levels for the entire time.

 

[Humblefish]

The nice thing about prazi is it does its job in about an hour, so degradation isn't as much of an issue. I'd be more concerned about microbes consuming other medications such as antibiotics, metronidazole, Chloroquine, etc. Those require more contact time.

 

[midwestE]

The nice thing about prazi is it does its job in about an hour, so degradation isn't as much of an issue. I'd be more concerned about microbes consuming other medications such as antibiotics, metronidazole, Chloroquine, etc. Those require more contact time.

The only other medication they mention also degrading is formalin. In that study, it seems to indicate therapeutic levels for only four of 24 hours. https://www.jzar.org/jzar/article/view/131/108

 

[Humblefish]

The only other medication they mention also degrading is formalin. In that study, it seems to indicate therapeutic levels for only four of 24 hours. https://www.jzar.org/jzar/article/view/131/108

IMO; formalin is best applied at a higher dosage (12 drops per gallon) in a 45 minute bath treatment.