I mean, if we quarantine for 72 days which is the prescribed time frame, the fish may lose it's immunity that it has from the sea.
The stuff we normally eat and breathe is different from the bacteria and pathogens a fish needs to stay immune. We don't generally eat live prey any longer although at one time we did. I am sure we lost our ability to process all those pathogens with our modern diet which is why every time I go to Mexico I get sick, but the Mexican people don't. And in the Year I spent in Nam I took an anti Malaria pill every day,but the local people did not have to. It is also the reason our POWs in Nam got malaria. We have no natural immunity to it because we are never in contact with it
I will keep my not malaria resistant existence. The semi-immunity of endemic populations requires repeated malaria infections. By age 5 if the child survives multiple infections they usually acquire this semi-immunity. But 70% of malaria deaths are children under the age of 5, that was over 700,000 in 2008. (Has significantly dropped since 2010 to 400,000 total deaths thanks to better controls, like mosquito control and bed nets).
Anthropologically, we have cooked our food for a very long time, fire first appears with H. errectus 1.4 mya. Though the first concrete evidence of cooking is .5mya. There also only 6000 hominid fossils actually discovered thus far, so this isnt evidence we havent cooked longer. From a dentition analysis we have at least chopped our meat since 3 mya. The lack of resistance to a regional E. coli population(primary cause of TD) has more to do with its large variation from population to population, location to location.
Long way of saying perhaps there are multiple ways of giving a healthy life to our fish. We have eliminated rinderpest from the world, does this make livestock less healthy since they will never be exposed to a now dead disease? If i never introduce ich to my tank are they less likely to live a long life, if i provide them a healthy fulfilling captive environment?