I dose daily.
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i cycle all my tanks with it ever since it came out...
I put in a clown and a clean up crew after 6 days. A couple of weeks after set-up I added the rest of the fish and started transfering my sunset monti frags, duncans, palys and an anemone. I was skeptical but I haven't had any losses and the tank has been running smooth so far.
I cycled one with nothing live in 3 days.. it works wonders... Used shrimp and mb7
The instructions say "To seed biological filtration in new aquaria: Add 5ml/25 gallons of water daily for the first two weeks." I got the big 2L bottle online.
I used it to setup my 20L.....and had corals in it a week after setting it up. Nothing died.