Bryopsis Cure: My Battle With Bryopsis Using Fluconazole

Did Fluconazole Kill all of your Bryopsis?

  • Yes

  • No

  • I'm treating my tank with it now.

  • I love Bryopsis and I'm mad that everyone is killing it.


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awais98

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I've always had idea about trying fluconazole and griseofulvin for our tank fungus but never got to it. I will try one day.
 
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awais98

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One of my worry is the zooxanthellae in our corals are also fungus.......hence i never tried it.
Once I have all my setup done, will one day get some sacrificial frags in a QT and try
 

jason2459

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jason2459

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I've always had idea about trying fluconazole and griseofulvin for our tank fungus but never got to it. I will try one day.
Its in fish medication for fugus treatments.
 

Sabellafella

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You are not alone, we are crossing our fingers as well. Do you know how many people have tore down their tanks and restarted or quit reefing all together because of this mess....This could really change things. We hope.
I have took down a nice qt before myself from bryopsis. Its a nightmare, my buddys trying the treatment in the next few days. Although hes 99% possibly not going to talk about it, i will document it myself. Its a big big problem for him, because he has 3 dt ,1 frag tank, 3 different plumbed tanks (1 sump 1 drain 1 fuge)that are all candidates in his system. Seems very confident, hopefully it works.
 

awais98

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Yes, and often prescribed for yeast infections of a female sort or even worse thrush among many other fugus type issues in humans.
Yes fluconazole are prescribed for single cell yeast/ candida infections, but not usually for higher forms of fungus.....
I know itraconazole et all can be used for branching but the cost would be prohibitive for hobby use.
I remember reading griseofulvin is a static drug but it is also effective for branching fungus.
Hence my idea for griseofulvin trial.
 

Sabellafella

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Yes fluconazole are prescribed for single cell yeast/ candida infections, but not usually for higher forms of fungus.....
I know itraconazole et all can be used for branching but the cost would be prohibitive for hobby use.
I remember reading griseofulvin is a static drug but it is also effective for branching fungus.
Hence my idea for griseofulvin trial.
Well hey! You never know =) maybe it could work against something else
 
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NCreefguy

NCreefguy

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I have took down a nice qt before myself from bryopsis. Its a nightmare, my buddys trying the treatment in the next few days. Although hes 99% possibly not going to talk about it, i will document it myself. Its a big big problem for him, because he has 3 dt ,1 frag tank, 3 different plumbed tanks (1 sump 1 drain 1 fuge)that are all candidates in his system. Seems very confident, hopefully it works.
Hopefully it works out for him.I have no idea how things in a fuge would react as I don't have one on this system now.(well i do but no macros currently)
Like someone in the other thread said this could be a part of our qt process in some way and nobody would have to worry about it anymore.
 

drawman

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I'm so confused what is the rationale for treating bryopsis with an antifungal I'm struggling to make any connection. I've seen a couple of these threads lately and I'm really curious as to how this trend started.
 

jason2459

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I'm so confused what is the rationale for treating bryopsis with an antifungal I'm struggling to make any connection. I've seen a couple of these threads lately and I'm really curious as to how this trend started.

Look up how it interacts.



Posted this in another thread on what may cause a reaction with bryopsis

....

This is cool and all

"This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane, and subsequent accumulation of 14α-methyl sterols.[20] Fluconazole is primarily fungistatic; however, it may be fungicidal against certain organisms in a dose-dependent manner, specifically Cryptococcus.[29]"

But its ability to disrupt this

"Fluconazole is an inhibitor of the human cytochrome P450 system, particularly the isozyme CYP2C19 (CYP3A4 and CYP2C9 to lesser extent) [27]"

I find most interesting. The cytochrome P450 system is not unique to humans or fungi. This also could disrupt the uptake of a vital element for bryopsis to live, Fe. Just a guess.

https://en.m.wikipedia.org/wiki/Cytochrome_P450


So, be warned if that's it it could effect more then bryopsis like many other microorganisms.

Like this interesting fact
"Cytochrome P450 eryF (CYP107A1) originally from the actinomycete bacterium Saccharopolyspora erythraea is responsible for the biosynthesis of the antibiotic erythromycin by C6-hydroxylation of the macrolide 6-deoxyerythronolide B."


Or

"
Plants
Plant cytochrome P450s are involved in a wide range of biosynthetic reactions and target a diverse range of biomolecules. These reactions lead to various fatty acid conjugates, plant hormones, secondary metabolites, lignins, and a variety of defensive compounds.[44] Plant genome annotations suggest that Cytochrome P450 genes make up as much as 1% of the plant genes. The number and diversity of P450 genes is responsible, in part, for the multitude of bioactive compounds.[45]"
 

drawman

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Look up how it interacts.
Very interesting. It's been a long time since I've taken any meaningful pharmacology, biochem, or physiology course and I guess I can't remember studying Cytochrome P450 outside of the human body.

That said, it is interesting to me still how someone came up with the connection that it would specifically target bryopsis (over other algaes, animals, etc.) and to a dose that wouldn't affect other organisms appreciably. Also since algaes aren't true plants the mystery deepens for me. Either way I will be following out of curiosity at least.
 

tigé21v

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Very interesting. It's been a long time since I've taken any meaningful pharmacology, biochem, or physiology course and I guess I can't remember studying Cytochrome P450 outside of the human body.

That said, it is interesting to me still how someone came up with the connection that it would specifically target bryopsis (over other algaes, animals, etc.) and to a dose that wouldn't affect other organisms appreciably. Also since algaes aren't true plants the mystery deepens for me. Either way I will be following out of curiosity at least.
Someone with a bryopsis-infested tank started dosing the med for their fish, and noticed the peculiar side effect, would be my guess.
 

drawman

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drawman

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The drug early on was used to treat cardiovascular issues, the unknown beneficial side effect was it treated errectile dysfunction. And the drug became forever known as viagra.

Another lucky arrow?
Yup exactly. Hypotension and hard-ons so it became much more effective with the latter.
 
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