I wouldn't leave my RO/DI system under pressure all the time. I have never had any issued with turning the system completely off at the source when not in use. Canisters have been known to fail, leak or even explode over time if pressure is strong enough, and under pressure, if one fails and your not home, that would equal a ton of water on the floor...
True and I've also heard the back pressure will harm the RO membrane. That is why they make a kit for systems that are hooked up to float valves.