My experience with high-dose interceptor

Biff0rz

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Back in March and April, I committed to a full-on, high-dose Interceptor treatment for my mostly-SPS reef tank—and what a journey it's been! I’d been battling a lack of polyp extension (PE) for ages, and while I never visually confirmed it, I had long suspected white bugs were lurking in the system. After years of frustration and random STN/RTN events affecting one or two corals every couple of months, I finally decided to go for it.

Some corals thrived, others sputtered along (looking at you, JF Jolt—held color but never grew), and a few just didn’t make it. I tried everything I could think of to get all my SPS happy and growing, but something always felt off. That’s what pushed me toward Interceptor. I first tried the chewable version and had some mild success… but the bugs (again, suspected—not confirmed) seemed to return. So I doubled down and went all-in.

I found a fish vet, got a proper prescription, and picked up a solid supply of the pill-based Interceptor. My total system volume, including the frag tank, is around 315 gallons, so my plan was to dose one large pill per 50 gallons each week—for six weeks. That meant six large pills per dose. A serious investment, but I was ready.

Weeks 1 to 3 were honestly pretty exciting. In the first week, I noticed a bit more PE on my acros—though still nothing major with my tenuis. Then weeks 2 and 3 brought a huge growth spurt! I could see daily changes—new growth at the base and tips of my acros. It felt like the tank had finally turned a corner.

But then came the “dark ages.” Weeks 4 through 6 were rough. Dino outbreaks exploded—seriously, everywhere. Algae started popping up on rocks, sand, pipes, pumps—you name it. I saw flashes of hair algae, cyano, diatoms… all at once. It was chaos. The tank’s bacterial balance clearly shifted hard, and it showed.

Corals across the board responded badly. My beloved King Kong shrooms shriveled up. All my LPS retracted. The acros and tenuis that had just started perking up lost their PE again—some even looked worse than before. TSA Carolina Reaper was the only acro still looking decent, but even that one eventually browned out. PE vanished, colors dulled. TSA The Fuzz went from “super fuzz” to flat brown. Tenuis, while paler, held onto some PE—which was at least something. To top it all off, my once-purple frag tank floor—previously covered in healthy coralline algae—turned into a mess. The coralline flaked off in chunks, clogging my gyres and leaving bare glass behind.

I did end up having two "losses". I put this in quotes because the corals are still alive. When the bacteria changed the bases of two corals started to STN. One is unnamed but the other, Garf Bonsai, is fairly well known. Almost the entire base turned white and I for sure thought I lost the coral. As time went on, it slowed and stopped. Oddly, PE & color was still good through all of it. I just have never seen a coral STN from the bottom up and not nuke the whole thing. But, here we are.

It was honestly heartbreaking. Seeing everything crash after trying so hard was tough—and I’ll admit, it got me pretty down. But I stayed the course.

My last Interceptor dose was in early April. And now, I’m thrilled to say the tank has finally bounced back! Dino’s are gone. The algae has receded (though I did use some Red Slime Remover to help). Corals are coloring up again—TSA Carolina Reaper is a vibrant mix of red and green and looking fuzzier than ever! My latest ICP results came back with normal, healthy levels across the board. Even the LPS and mushrooms are perky and happy again.

I do still have a few acros in recovery mode—low-ish PE, still a little green—but they’re slowly improving. Honestly, I’m just so excited to see the tank finally stabilizing and thriving again.

It’s been a long and bumpy road, but I wanted to share my experience so others know what to expect when going down this path. If you’re considering a serious Interceptor treatment, know that it can work—but it might test your patience and your tank’s resilience along the way. Hang in there. The recovery is worth it!



I took a video over the weekend of some of my corals, I'll put some comments about each one below -- each link is to the same video but I mark times at which each coral noted below appears

TSA Bubble Yum (tenuis)

Before: Pale, low coloration, no PE
After: Coloring up, blue's and pinks, lots of PE!

JF Blow Torch (tenuis)

Before: Nice colors, zero PE
After: Colors still recovering but you can see pinks/reds/blue's. Lots of PE! Lot's of growth too, lots of new branches forming near the base in the vid

CC Disney JR (tenuis)

Before: hyper pink coloration, minimal PE
After: Pink is returning, not as vibrant yet. PE is still recovering but all are present and coming out! Back behind it you can see WWC Heartbreaker (went green during treatment)

POTO Side Chick (acro)

Before: slow growth, nice colors, low PE
After: Colored up even more, lots of fast growth, and lots of PE!

TSA Carolina Reaper (acro)

Before: Bright red colors, lush PE, fast growing
After: Still coloring up, mid-way imo, MORE PE, growth returning

CC Pink Highlighter

Before: Nice pink color, nothing else color-wise, low low low PE, slow/no growth
After: Multiple colors -- pink, yellow, blue, lots of PE, and growth branches!

TSA Princess Peach

Before: Nice colors but not full, good PE, not great, mid growth
After: Colors returning (went all brown), still low PE but it's out at night, growth back to a mid-rate.

TSA Skywalker Millie

Before: No colors (green-ish), No PE, no growth
After: Color! Lots of PE, as it should be lol, and growing at the base like crazy!

JF Jolt -- this one I'm super happy about

Before: No growth, no color other than blue, no PE, notorious slow-grower
After: Colors, LOTS of them! Red polyps, blue branches, even some greens/yellows. Growth is going fast at the base, and seeing some new branches sprout up!

Vivids Confetti

Before: Slow growth, nice colors, mild PE
After: Fast growth, more vivid colors, lots of PE!

Bahama Mama Millie

Before: No growth, no color, no PE
After: Noticing some base growth, its got some color and PE now!! wooo!

Needless to say, I'm super happy with my results! I hope this post helps someone else in some way.
 

KrisReef

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My tank has shown a remarkable ability to bounce back with new unexplained deaths for too long. I have ivermectin in the refrigerator waiting for me to try to kill the bugs but I just don't have the nerve, yet.

Thanks for this encouragement.
 
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Biff0rz

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My tank has shown a remarkable ability to bounce back with new unexplained deaths for too long. I have ivermectin in the refrigerator waiting for me to try to kill the bugs but I just don't have the nerve, yet.

Thanks for this encouragement.
Do It Episode 3 GIF by Star Wars
 

Necrodaemus

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This exactly what terrifies me about doing a stronger, 3 week run. A few months ago I did one round of Interceptor at 2x strength and it definitely made an impact on the whitebugs....couldn't see anymore, PE improved and growth picked up. A month later I started seeing more. That one round resulted in some increased algae growth but nothing major or out of control.
 

saltyfins

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My tank has shown a remarkable ability to bounce back with new unexplained deaths for too long. I have ivermectin in the refrigerator waiting for me to try to kill the bugs but I just don't have the nerve, yet.

Thanks for this encouragement.
dont do it! I know someone who nuked their tank trying. heartbreaking
 

KrisReef

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dont do it! I know someone who nuked their tank trying. heartbreaking
Yes, I have been thinking of just using Ivermectin for dips and currently getting milbemycin for the DT.

I'm not sure how hard to hit the tank, other sites suggest (slightly less than) 23mg/200 gallons for three treatments, the OP seemed to be using ~ 4 times that strenght.

I want to clean the tank but not over dose if possible.
 

carri10

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Hi. Given what Interceptor is supposed to be toxic against, what do you think died that knocked that tank out of balance?
 

Tonycass12

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Hi. Given what Interceptor is supposed to be toxic against, what do you think died that knocked that tank out of balance?
Im curious on this as well aslo wondering what age of the tank was. My 6x dose also had prazi and knocked out any and all flatworms in my tank.
 

freepizza80

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I'm seriously thinking about using interceptor. Just sick of acro "surviving" when they used to thrive. I've checked pretty much everything else. All test/ICP results always come back perfect. One thing I'd do before the treatment is to remove my snails and crabs, as many as I can. That probably will help with the “dark ages.”

Does anyone know how long before I can safely put those snails and crabs back in after the treatment?
 

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Snails not necessary to remove. Treat 3 times. Put crabs n shrimp back at least 24 hours after 3rd treatment
 
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Biff0rz

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Hi. Given what Interceptor is supposed to be toxic against, what do you think died that knocked that tank out of balance?
Not sure really, but, my guess is it disturbed the tanks overall bacteria balance and caused things to go haywire.

Through the whole thing I kept dosing reef moonshiners and doing param tests. Nitrates and po4 were normal for me through the whole thing and when I did an ICP, nothing crazy showed up on the report.

Im curious on this as well aslo wondering what age of the tank was. My 6x dose also had prazi and knocked out any and all flatworms in my tank.

My tank is about 5 years old now.

I used the chewables the first time but with so much sps I didn't want to risk the prazi in it. Finding a vet to help me was actually easier than I thought and cost me $70. They were also able to Rx me more Interceptor than what Chewy would sell to me even with an Rx.

If you want to risk using the Chewables, go for it. It just wasn't for me!

How about a new PE video?
Almost all of the corals in this video pre-interceptor had about 0 PE, some are the same as the video above, about a month later. As you can see, better colors, better PE, and the algae beside them is now gone.
 

mfollen

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Thank you for sharing! How do you think you got through the dinos? I’m in a similar situation now after a treatment.
Thanks!
 
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Biff0rz

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Thank you for sharing! How do you think you got through the dinos? I’m in a similar situation now after a treatment.
Thanks!
Just keep up regular maintenance, let the tank naturally re-balance, let it re-build pods, and eventually it comes back. Mine took about 2mo post-treatment to get back to normal. If you have bad cyano, like I did, you can use red slime remover. But just let the dino take its course. You might lose a frag from it but you can do the usual of blowing it off or moving the frag to try and help it. More than likely the coral was probably weak to begin with if dino sets it over the edge.
 

Necrodaemus

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Finished up a 3 week regime of dosing Interceptor (4x dosage) 2 weeks ago and I'm happy to report no more bugs to be seen. Acro PE has never been better and seeing PE on some pieces that had stalled out with no PE for months. I'm seeing munid idopods in the refugium still and both wildcaufht mandarin and red scooter are still fat, happy, and seen pecking at rocks. The worst of it was I lost all of my hermits (didn't want to remove and reintroduce as to prevent the chance of bringing the bugs back). There's definitely more algae growth on the rocks but nothing that's getting out of control....blenny and tangs are grazing like crazy.
 

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Im finishing up my coral collection for my 40 breeder and once I do I’ve thought of trying inercepter and won’t be adding anything else that would reintroduce bugs after treatment. If I decided to add something I would quarantine with interceptor but anyways, I have a few questions. Are any corals, more affected by interceptor? I understand there’s risk to any but are there any that would be at more risk of significant harm. Also, I know shrimp, crabs, pods but what about inverts without exoskeletons like snails, conchs etc.? How long before you can reintroduce shrimp/copepods? I figure it’s best to take hermits to lfs if they would take them but I’ve had this CBS for a couple years and rather keep him. I don’t mind setting up a 10g or something for it and any other coral/inverts that won’t reintroduce bugs after treatment like inverts with shells. I’ve had my fighting conch for a couple years too but i guess I could take it to lfs and put in a display if needed. Can’t you just dose copepods afterwards? Most importantly, I’ve been having more success with tenuis than I have in the past. I get some PE but nothing like the extension others have after treatment. Is it really worth it? Taking a chance, I don’t have the money to just restock/replace if it crashes, for that reason I don’t think I’ll do it but I’m thinking about it. More research will be done.
 

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Im finishing up my coral collection for my 40 breeder and once I do I’ve thought of trying inercepter and won’t be adding anything else that would reintroduce bugs after treatment. If I decided to add something I would quarantine with interceptor but anyways, I have a few questions. Are any corals, more affected by interceptor? I understand there’s risk to any but are there any that would be at more risk of significant harm. Also, I know shrimp, crabs, pods but what about inverts without exoskeletons like snails, conchs etc.? How long before you can reintroduce shrimp/copepods? I figure it’s best to take hermits to lfs if they would take them but I’ve had this CBS for a couple years and rather keep him. I don’t mind setting up a 10g or something for it and any other coral/inverts that won’t reintroduce bugs after treatment like inverts with shells. I’ve had my fighting conch for a couple years too but i guess I could take it to lfs and put in a display if needed. Can’t you just dose copepods afterwards? Most importantly, I’ve been having more success with tenuis than I have in the past. I get some PE but nothing like the extension others have after treatment. Is it really worth it? Taking a chance, I don’t have the money to just restock/replace if it crashes, for that reason I don’t think I’ll do it but I’m thinking about it. More research will be done.
I have a mixed reef that's SPS dominant. Interceptor had no adverse affects on any of my corals.
 

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