By far the best skimmer for this tank and yes it fits in the second chambers so you can still use filters in the first chambers.Not sure on the dimensions/space you have but I was going to put this in my Nuvo 60 might fit yours also. I don't know much about skimmers.
Curious to know what skimmer others use in their Nuvos. Have read a lot of negative reviews about the ghost skimmer and a $300 skimmer for my tank is too much IMHO, unless I was trying to keep it hidden. Your tank requires the next step down ghost skimmer.