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Thank youIf it were me I would say do at least 10% water change and run carbon for quick removal. It is not completely necessary as bacteria and light degrade the medicine over a fairly long time. If you plan to dose again though I would do the bigger water change because you don't know for sure how much is left in system.
Water change.I am finishing my second dose of Praziquantel is it necessary to do a 30% water change or should I let it dissipate on its own. Thanks for any advice
30%Water change.
You can just let it dissipate (actually, it gets decomposed by bacteria). Water changes never hurt of course but they aren't necessary with normal dose praziI am finishing my second dose of Praziquantel is it necessary to do a 30% water change or should I let it dissipate on its own. Thanks for any advice
You can just let it dissipate (actually, it gets decomposed by bacteria). Water changes never hurt of course but they aren't necessary with normal dose prazi
Jay
No - I can test chloroquine with a UV spec, but not prazi. Disney did a study that showed with subsequent treatments, praziquantel levels were reduced faster and faster. They then determined it was being consumed by bacteria. I had observed years before this, that prazi treatments used on the same tank, time after time, simply stopped working. I had erroneously thought the flukes were developing a resistance to prazi, when actually the bacteria population had grown enough to consume the prazi before it had time to work.Jay, are you guys able to test prazi levels? I thought I remember reading after 24 hours, it was basically gone?
Since you are familiar with CP can you inform me how much of a dosage for a 620 gallon tank and what is the dosage recommendations such as how many days etc. I really appreciate it Thanks for your time I bought a lot of CP but never used it since no one really knows the amount and length of dosage Fish Only I have. Thanks againNo - I can test chloroquine with a UV spec, but not prazi. Disney did a study that showed with subsequent treatments, praziquantel levels were reduced faster and faster. They then determined it was being consumed by bacteria. I had observed years before this, that prazi treatments used on the same tank, time after time, simply stopped working. I had erroneously thought the flukes were developing a resistance to prazi, when actually the bacteria population had grown enough to consume the prazi before it had time to work.
Jay
It can take well over 30 days to be biodegraded. More likely that it is reacted with light and or oxidized to an easier form to be degraded. One would typically do a water change before it is completely gone anyway. It would be best to do at least a little water change though because these meds can stress fish out, possibly cause health problems over long periods, react with other things in the water, and or cause resistance like you mentioned. What type of fish did you treat?
I haven't used chloroquine for four or five years. I ran into some toxicity issues with lionfish and wrasses at 15 mg/l, and going down to 12 mg/l wasn't giving me good disease control.Since you are familiar with CP can you inform me how much of a dosage for a 620 gallon tank and what is the dosage recommendations such as how many days etc. I really appreciate it Thanks for your time I bought a lot of CP but never used it since no one really knows the amount and length of dosage Fish Only I have. Thanks again
I know some more of the background on this study, it is heterotrophic bacteria that causes the degradation. There aren’t any byproducts except normal metabolic waste.I would still do a little water change, their tests only used 2ppm vs others using 5x more in a non controlled experiment to treat home fish. Also never mentions the degradation biproducts which in itself could have impacts. That is where I would err on the side of caution. The study I read didn't mention salt water bacteria only environmental exposures.
Sorry, you've confused me. I had to run a Google search - that is from a paper discussing Phragmites wetlands removing Praziquantel. The "21 compounds" weren't identified, and there is no way to know if some/all weren't part of a degradation pathway that is common with bacteria (protein to ammonia to nitrite to nitrate as an example). There is a huge difference between metabolites and TOXIC metabolites. Beware of over-extrapolation from non-related studies.I disagree "The accumulated anthelmintic compound was partly metabolized, and twenty–one compounds were identified." This was in the case of run off from farms analyzed in plant cell walls.
How long would you leave it in tank (CP) one dosage or several?I haven't used chloroquine for four or five years. I ran into some toxicity issues with lionfish and wrasses at 15 mg/l, and going down to 12 mg/l wasn't giving me good disease control.
To calculate the amount of a product to use, here is the formula: exact gallons to be treated multiplied by the target concentration, divided by 266 give you grams of medication to use. So - lets say the 620 gallon tank actually holds 575 gallons and you want to treat chloroquine at 15 mg/l Therefore: 575 * 15 / 266 = 32 grams
Jay
I wouldn't re-dose chloroquine more often than once every 30 days unless you can measure the amount remaining (and that requires a UV spectrophotometer). The only time you should re-dose sooner is if you change some of the water, and then, you should re-dose 100% based on the amount of water that your changed. Don't use a UV sterilizer or carbon when running CP.How long would you leave it in tank (CP) one dosage or several?
ThanksI wouldn't re-dose chloroquine more often than once every 30 days unless you can measure the amount remaining (and that requires a UV spectrophotometer). The only time you should re-dose sooner is if you change some of the water, and then, you should re-dose 100% based on the amount of water that your changed. Don't use a UV sterilizer or carbon when running CP.
Jay
Praziquantel is broken down by bacteria much faster than 30 days after multiple treatment.. 8 days for the first treatment and 2 days for the next. The bacteria population grows: rapidly in response to the presence of prazi to work on. Here is the reference:
Praziquantel degradation in marine aquarium water
Praziquantel (PZQ) is a drug commonly utilized to treat both human schistosomiasis and some parasitic infections and infestations in animals. In the aquarium industry, PZQ can be administered in a “bath” to treat the presence of ectoparasites ...www.ncbi.nlm.nih.gov
We found that after 4 treatments, the bacteria population was so great that the praziquantel was removed before it had any real benefit in removing flukes from flashlight fish.
Jay