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Hi there @Josh8587 . Welcome to R2R! I'm very sorry about your gramma.
It does indeed look like an infection to me. I would advise antibiotics, in a QT is best. The problem is that these infections are often secondary to another problem like parasites (ich, flukes, ect). Since none of the fish have been QT'd, that is a distinct possibility. Another is that it's an injury that got infected... so, are there any bullies in the tank? Hitchhikers that may go after him? Crabs?
The Yellow Tang seemed to slightly chase her a little, but not alot. We do have a Sally Lightfoot but I haven't noticed any aggression.
Unfortunately, we woke so find she had died last night. Whatever it was, it happened fast. I know it's only a fish, as some friends would say, but I feel as though they trust their life to us and we let them down. Kinda bummed.
Thanks for all the help so quickly. I think a quarantine tank is in our future.