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Yes, something happened, no doubt, but considering hundreds of cases of Fluconazole use without reporting similar side effects, attributing the same damage to Fluconazole that everyone used is difficult. On the other hand, coral bleaching also occurs due to other causes, especially oxidative stress, and there is no evidence that Fluconazole causes oxidative stress due to its mechanism of action.
Best regards
all my SPS doing great did see a bit of faded colors for the first few days but all look good now
hmnnn so it seems that you saw the same/similar issue as i did. perhaps not to the degree that I did though. I sure hope i don't loose any more of these corals that i grew from frags.
Overall i would have to say if i had to do this treatment over i would not knowing what happened to alot (but not all) of my sps corals. only reason I did go through with it in the first place is the overwhelming positive results displayed here in this thread. I just wasnt paying attention that most of these people were not growing SPS corals. aggrrrr.
I had a few sps frags that rtn'd and the only thing I did differently was treat with flucanzole. I cannot say for sure that's what caused it but it's what i suspect. I'm not sure if a phosphate/nitrate increase from die off could be the cause or the flucanzole itself. It did get rid of most gha but I've since had some return. I have flucanzole left over but I'm hesitant to try it again and risk killing more of my sps
My main tank is mostly SPS and hasn't had a water change in months after the flucon treatment. We've got 7 different systems set up in our shop with everything from frag systems to SPS/LPS systems and we are not having any issues with using Fluconazole in any of them. Some of our systems are getting a constant replacement of low dosage Flucon and some are close to a year with no water changes. I've got to agree with @Jose Mayo on this one and say that you may have had some kind of contaminate in your capsules or something else went wrong for that much loss in your system.