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Oh I guess I should've asked this too...it's safe to start these antibiotics at any stage during cupramine treatment? Just started yesterday slowly. How slowly? I have a 20 gallon. Only dosed .5 ml instead of the 1 ml per 10.5 on day one. Gave another .5 ml today. So tomorrow doing another .5 ml. So I should be to lower therapeutic levels tomorrow. Then I can start my 30 day countdown.@reynaldoramon Very likely the beginnings of a secondary bacterial infection, which is quite common in fish with a preexisting parasitic infestation such as ich. I would add a broad spectrum antibiotic (exs. Kanaplex, Furan-2) to the mix. Or you can combine Kanaplex, Furan-2 and Metroplex for a very powerful antibiotic cocktail.