I assume they don’t expect any issues if you follow their instructions bc they formulated and designed the dosing to safely lower po4 for the consumer. No diluting or extra math required. 1ml/26 gallons/day. Which is great for a dumb, lazy reefer like me.
The printed instructions that came on the bottle I have don’t say anything about dosing into the skimmer. They state that results are better in systems with a skimmer or mechanical filtration. It also lists the maximum daily po4 reduction tropic marin recommends and their recommended ranges, which I find are way too low.