CBB rescue mission. Help please.

[Brew12]

There is a long thread on a forum here with over 6 years of experiences swapped etc.

The prophylactic consensus has been adjusted over time and they are all happy with the amount they use now. It has been stickied on the forum I speak of.

They thought 3 tablets for my 55l was the higher side. Interesting how you guys over there think different..

You could be on to something. I just found this while digging into it more.

http://www.diamondbackdrugs.com/chloroquine/

The typical treatment involves adding five to ten milligrams of Chloroquine per liter of water every five days for a minimum of four treatments. However, your veterinarian or aquarium specialist will provide more detailed instructions for treating your unique case.

Along with this

The water’s salinity level should be maintained under 14ppt, and the tank light should be left off during treatment.

 

[Humblefish]

You could be on to something. I just found this while digging into it more.

http://www.diamondbackdrugs.com/chloroquine/

The typical treatment involves adding five to ten milligrams of Chloroquine per liter of water every five days for a minimum of four treatments. However, your veterinarian or aquarium specialist will provide more detailed instructions for treating your unique case.

Along with this

The water’s salinity level should be maintained under 14ppt, and the tank light should be left off during treatment.

Yeah, I saw that and have been puzzled by it. I'm guessing the reasoning for redosing every 5 days is to account for biodegradation? But then you risk overdosing the medication.

I can't find anything which discusses the half-life of CP in water. However, being CP is originally a malaria drug I did find this:

A metabolite of chloroquine – hydroxycloroquine – has a long half-life (32–56 days) in blood and a large volume of distribution (580–815 L/kg).

Source: Molina DK (2011) Postmortem hydroxychloroquine concentrations in nontoxic cases. Am J Forensic Med Pathol

The thing about maintaining SG under 14ppt is probably unsubstantiated, and the "CP light myth" was debunked by a public aquarium employee on here who was using CP under 400k MH and was testing daily using a spectrophotometer. He noted CP remained remarkably stable until after a few months when (presumably) heterotrophic bacteria would begin to consume it.

 

[Humblefish]

I will say it's probably not a good idea to run lights whilst using CP to treat a fish with velvet; only because velvet causes fish to be sensitive to light.

 

[Brew12]

Yeah, I saw that and have been puzzled by it. I'm guessing the reasoning for redosing every 5 days is to account for biodegradation? But then you risk overdosing the medication.

I can't find anything which discusses the half-life of CP in water. However, being CP is originally a malaria drug I did find this:
Source: Molina DK (2011) Postmortem hydroxychloroquine concentrations in nontoxic cases. Am J Forensic Med Pathol

The thing about maintaining SG under 14ppt is probably unsubstantiated, and the "CP light myth" was debunked by a public aquarium employee on here who was using CP under 400k MH and was testing daily using a spectrophotometer. He noted CP remained remarkably stable until after a few months when (presumably) heterotrophic bacteria would begin to consume it.

They don't mention water changes or filtration either, so it could be that it ramps up the concentration over 20 days.

I think this needs to be added to the long list of treatments that need more scientific studies.

 

[Biznizface]

This is the bible for CP use over here if anyone's interested .. a near 6 year old thread..

http://www.ultimatereef.net/forums/showthread.php?510239-Chloroquine&highlight=Chloroquine

 

[Brew12]

This is the bible for CP use over here if anyone's interested .. a near 6 year old thread..

http://www.ultimatereef.net/forums/showthread.php?510239-Chloroquine&highlight=Chloroquine

Wow, what a source of experience! I can't wait to dig into it. That could take awhile but it looks to be a great listing of peoples experiences using CP.

 

[Nick James]

Good read everyone, thanks. Is there a common QT regiment for CBB of any Butterflyfish really if they are not showing any signs of illness? I am looking at setting up a QT soon for a CBB that will be my first fish for my 220g tank. This is my first time using a QT, I've been lucky in the past and want to do it right moving forward.

 

[Humblefish]

Is there a common QT regiment for CBB of any Butterflyfish really if they are not showing any signs of illness?

It's important to get them eating first before starting any medications. Unless you see active signs of disease.

If "red sores" pop up (common bacterial infection butterflies sometimes get), dose this ASAP: http://store.nationalfishpharm.com/NFP-products-Nitrofuracin-Green-59584.Item.html

 

[Nick James]

Thanks humble. Aside from that situation, I am looking for a "basic" QT regiment for new fish. I have to look back through your threads to see if you outlined this schedule.

 

[Humblefish]

Thanks humble. Aside from that situation, I am looking for a "basic" QT regiment for new fish. I have to look back through your threads to see if you outlined this schedule.

TTM used to be my "go to" QT protocol, but the prevalence of velvet has forced me to rely more on copper or CP. Maybe velvet isn't as common coming from Canadian wholesalers?

See blue links for more reading.

 

[MamaLovesHerReefTank]

TTM used to be my "go to" QT protocol, but the prevalence of velvet has forced me to rely more on copper or CP. Maybe velvet isn't as common coming from Canadian wholesalers?

See blue links for more reading.

Velvet is here in Canada as well. We have one LFS here in Ontario that we don't dare buy from anymore. They are only about trying to make a sale.