Let's say we are the fish - all living together in the ocean, where QT doesn't happen but pathogens only exist in (relative) low numbers. Overall, we are fine unless our population grows to the point where we are fueling disease to an unmanageable level (fyi, this is also what typically happens in a closed system.) Humans have been damaging the environment for a long time now, but our exploding population has caused a tipping point.
What's the solution? To reduce the "surface nuisance" population back down to non-offending levels. Sounds harsh, but one of the things I admire about Mother Nature is how quickly she recovers after she seemingly destroys herself. We probably won't bounce back as quickly. So, the balance will shift back in her favor. Not a perfect solution (for us), but it will restore the planet back to a healthy state for any lucky survivors.