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I think there is some clarification to the question that is needed. Are you talking variation between tests, which are administered at roughly the same time every day? Or are you talking about variation with the 24 hour period, which wouldn't be captured in the previous testing scenario?
In the first case I would say as little as possible (Consistantly (x) dKH every day at (y) Time).
In the second case, There will be some fluctuation, the extent depending on your livestock and how you dose. Even with a DOS splitting your daily dose over 24 hours you would still have fluctuation due to corals uptaking Alk & Cal at different rates during the day and night.
Testing at different times during the same day the min and max swings (I think is how its meant). Alk varies in the ocean itself during the day - I'm not sure there is a benefit to trying to keep it at a certain number 24/7.