It is, but it’s surprisingly hard to do correctly!
— for a number of reasons; including the fact that new silicone doesn’t bond very well to old silicone, replacing a panel on a rimmed tank is a significant challenge! (It can often be more reliable to just rebuild the tank at this point!)
Edit:
after further consideration, the best-bet here short of replacing this sump would be to silicone a new plate of at least equal thickness over both of those bulkhead holes, effectively sealing them off! Then, re-plumbing your drains to go straight into the top of the sump so they aren’t at risk of putting stress on the glass!