Hydroxychloroquine Sulfate

[Paulo_Junior]

Hi guys,

I'm from Brazil and here is hard to find CP, can I replace CP by hydroxychloroquine?
Can I use the same dose than CP?

Kind regards,

 

[melypr1985]

I'm not very familiar with that medication but my gut says no. Let's tag @Humblefish so he can give us the real deal on this.

 

[Humblefish]

I'm pretty sure @alprazo tested Hydroxychloroquine and it failed to treat ich, velvet, etc. :(

 

[Halal Hotdog]

I'm pretty sure @alprazo tested Hydroxychloroquine and it failed to treat ich, velvet, etc. :(

Bringing back an older thread. Hydroxychloroquine is a lot less toxic to humans then chloroquine phosphate, however they overlap considerably for treatment. I’m curious if you could elaborate the failure that occurred? I’m curious if the efficacy is similar, but less toxic for fish then we might be able to avoid that lethargy that stops the feeding response at higher doses. Also might work on wrasses and regal tangs.

 

[Humblefish]

Bringing back an older thread. Hydroxychloroquine is a lot less toxic to humans then chloroquine phosphate, however they overlap considerably for treatment. I’m curious if you could elaborate the failure that occurred? I’m curious if the efficacy is similar, but less toxic for fish then we might be able to avoid that lethargy that stops the feeding response at higher doses. Also might work on wrasses and regal tangs.

@alprazo would need to explain, as I myself have not experimented with Hydroxychloroquine Sulfate.

 

[alprazo]

@alprazo would need to explain, as I myself have not experimented with Hydroxychloroquine Sulfate.

It has been probably a decade since my first experimentation with the antimalarial drugs, initially velvet, then later ich. At the time I experimented with quinidine, chloroquine and plaquenil / hydroxychloroquine. I don’t remember my dosing schedule with plaquenil but what I recall is that the fish I tested all died. I believed it to be from toxicity and not lack of efficacy. Quinidine was effective but the price was crazy and it was nearly impossible to obtain in my area. Chloroquine was also in short supply but since I was using it for some dermatomyositis patients at that time it had access to it. As you mentioned, hydroxychloroquine had greater availability, I was far more familiar with it, it has a better side effect profile in humans and less expensive. I was able to find the use of chloroquine in aquaria for algae and historical reports for velvet so I tried that first, had success and only tried hydroxychloroquine once.

 

[Humblefish]

It has been probably a decade since my first experimentation with the antimalarial drugs, initially velvet, then later ich. At the time I experimented with quinidine, chloroquine and plaquenil / hydroxychloroquine. I don’t remember my dosing schedule with plaquenil but what I recall is that the fish I tested all died. I believed it to be from toxicity and not lack of efficacy. Quinidine was effective but the price was crazy and it was nearly impossible to obtain in my area. Chloroquine was also in short supply but since I was using it for some dermatomyositis patients at that time it had access to it. As you mentioned, hydroxychloroquine had greater availability, I was far more familiar with it, it has a better side effect profile in humans and less expensive. I was able to find the use of chloroquine in aquaria for algae and historical reports for velvet so I tried that first, had success and only tried hydroxychloroquine once.

Good to see that you're still around, my man!

 

[Halal Hotdog]

It has been probably a decade since my first experimentation with the antimalarial drugs, initially velvet, then later ich. At the time I experimented with quinidine, chloroquine and plaquenil / hydroxychloroquine. I don’t remember my dosing schedule with plaquenil but what I recall is that the fish I tested all died. I believed it to be from toxicity and not lack of efficacy. Quinidine was effective but the price was crazy and it was nearly impossible to obtain in my area. Chloroquine was also in short supply but since I was using it for some dermatomyositis patients at that time it had access to it. As you mentioned, hydroxychloroquine had greater availability, I was far more familiar with it, it has a better side effect profile in humans and less expensive. I was able to find the use of chloroquine in aquaria for algae and historical reports for velvet so I tried that first, had success and only tried hydroxychloroquine once.

@alprazo Thank you for explaining what happened. I did have a couple of follow up questions. A decade is a long time so definitely understand if you don't recall. Do you recall which fish you treated with plaquenil? Do you recall the dosage you used? I have access to plaquenil and was thinking of trying it out due to the fact it is less toxic in humans in relation to cholorquine phosphate.

 

[alprazo]

I would have taken to typical dose of 200 mg. And with the avg adult weighing 60 kg. I would have used around 3 - 3.3 mg/l. So I’m pretty sure I used 12 mg/gal. And that does ring a bell. I never needed to re-dose because they died. Btw. It wasn’t quinidine I used, it was quinacrine. It was very hard to source an expensive but I believe that it worked.

As I sit in isolation writing this while in self quarantine from a prolong moderate risk exposure, I think that you might want to save that plaquenil though...... at least for a little while. The anti inflammatory activity might help with that dreaded cytokine storm.

 

[Halal Hotdog]

I would have taken to typical dose of 200 mg. And with the avg adult weighing 60 kg. I would have used around 3 - 3.3 mg/l. So I’m pretty sure I used 12 mg/gal. And that does ring a bell. I never needed to re-dose because they died. Btw. It wasn’t quinidine I used, it was quinacrine. It was very hard to source an expensive but I believe that it worked.

As I sit in isolation writing this while in self quarantine from a prolong moderate risk exposure, I think that you might want to save that plaquenil though...... at least for a little while. The anti inflammatory activity might help with that dreaded cytokine storm.

I have two fish coming in next week and am thinking of trying plaquenil on them. Due to the times I am unable to source chloroquine phosphate.

@alprazo toxicity issues at 12 mg/gallon, where CP recommended dose is 40 mg/gallon. I typically have success with CP around 10-20 mg/gallon, I find many tangs haven’t tolerated 40 mg/gallon in my system. For malaria treatment dosage is similar for both medications, which is a bit disheartening to finding a starting point. Do you recall how long it took the fish to start deteriorating after being introduced into the medicated tank?

@Humblefish do you recall the dosage you used and fish still presented with external parasites?

 

[alprazo]

As I recall the fish were dead the following morning. Unfortunately I can’t remember the exact fish tested. I was using small pompano, permit, mullet mostly because they where readily susceptible to the velvet strain I had and readily available, whereas the mummichugs, sheepheads minnies and killifish seemed a little more resistant. I was also gifted dying fish from the LFS back then, but I usually didn’t use those until I was convinced the med worked. It could have been any of the above though. My setup was a rubbermaid trash can and a power head with a Venturi. No light, room temp, no filtration. It was artificial seawater.

I’m sure I wrote about it at the time of you search other forums, but prior to trying different meds I was also able to create an immunity to the velvet with UV sterilization and or frequent water changes for about a month’s time I think. They seemed velvet free, only for it to comeback with an outbreak if something stressed the tank like a power failure. I haD a nicely stocked 300 gal tank with what I thought were immune fish. It seemed long lasting but ultimately ended in failure. It only took one fish to get sick with velvet and it went through the tank as if it were newly introduced.

I would not rec trying the plaquenil as a prophylactic.

 

[Halal Hotdog]

After reading your post I went through my QT boxes and found some CP, will take your advice and stick with that for the new fish I have coming in. I’ll try to contact my LFS and see if they have confirmed velvet fish that they are not equipped to treat. I really want to see how well plaquenil does on conformed sick fish.

 

[Ocypode sinensis]

After reading your post I went through my QT boxes and found some CP, will take your advice and stick with that for the new fish I have coming in. I’ll try to contact my LFS and see if they have confirmed velvet fish that they are not equipped to treat. I really want to see how well plaquenil does on conformed sick fish.

Hi, may I ask about what happened with your trial on Plaquenil/hydroxychloroquine? Did it work against ich/velvet?

 

[BigDaddyHouseboater]

I also would like to know.