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I would frame the inside in with 2x4 and put 3/4 inch plywood on top so the whole aquarium is supported. On the inside all you have to do is build a box on top and bottom with a support every 18 inches if your span isn't far then just the corners as uprights. Basically think of two boxes with legs connecting them and a cross brace front to back on the top box. I hope I described it well enough. Mdf doesn't support much weight and swells if it gets wet so it's best to have the inside framed carrying the weight with the mdf just there for aesthetics. Those boards attached to the back won't help much