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Hi. When you say instead of, are you referring to continuous use in place of an RODI!. An RODI will give you purified water by perminantly removing much more than prime will. And prime will only remove elements such as NO2/NO3 and ammonia for 48 hrs. After which time they could be released back into the water if your bio filter hasn't broken them down effectively. After which time you would need to redose prime.Can I use Seachem Prime Water Conditioner instead of RODI water? Thanks!