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Right - you only quoted part of my post - which said 'which is worse treatment of a disease or the possibility of metabolites'- or something like that. In any case. I was not talking about using prazipro in a display tank - or in a tank the fish would be exposed to for a long time. It was more like the case of a QT tank - in which case, all of the drug is gone after 9 days. The mercury analogy is interesting - I would presume that metalo-metabolites would be longer lasting than purely organic compounds. I.e. one reason not to use copper in a display tank. It does make me wonder - If you use natural fish food (i.e. live clams, etc - or even Frozen LRS) routinely - do you think mercury from the food will build up in the tank (the metabolites?)That´s how must people will understand that article - but - it is always a but - these articles only deal with the original substances and knowing that MFO is involved in fish and that the breakdown in water probably are done by bacteria rise the question of metabolites. As an example - metallic mercury is not of concern for us but when it comes out in nature - bacteria convert it into Methylmercury that can be bioaccumulated. If you try to search for metallic mercury in sediment - you can think it is of no concern because it is not there - but its metabolite is - and it is deadly for us.
Sincerely Lasse