I am frequently asked what my process is for QT, so I am just creating a thread that I can link users to for a reference. On arrival day, I match salinity in QT to arriving fish or make sure it's a touch lower (Usually 1.018). Acclimate (float for 30-45min in bag and release) fish directly into a QT that is pre-dosed to 1.0ppm copper (copper power) upon arrival. This is much safer than drip acclimation and removes the possibility of ammonia exposure during acclimation. I start fish off on food soaked general cure + Focus day one (continue for 14 days). I do also keep live food on hand and feed live foods as well for the first few days until the picky eaters and others are eating frozen well. Dosage for food soaked meds: Add 1 scoop of GC (scoop that comes with focus) + 1 scoop focus per 1 tablsespoon of prepared frozen food. I add selcon + a touch of garlic to help dissolve the meds. *You can also use Metroplex in place of general cure, it does however only treat for intestinal parasites instead of intestinal parasites + worms*. This food can be refrigerated once medicated. Is for 3-5 days, toss and make new. Then I spend the next three days raising cu level to 2.0PPM. increasing the level .25ppm per day or several small doses (the time is less important than the small increments). I do this by dosing half of the daily increase in the am and the other half in the pm. At this point I am watching very closely for external symptoms of bacterial infections. If one arises or a fish prone to infection stops eating then I dose Spectogram (Kanamycin+Nitrofurazone) and continue throughout copper. You can also use Kanaplex+furan-2. The WCs are fun maintaining the therapeutic Cu level. But once you have the hang of it, it's not bad. Copper has to be pre-dosed into new SW prior to adding to tank to keep Cu level from dropping below therapeutic. https://www.reef2reef.com/threads/ratios-for-dosing-copper-power.385871/ Also, If you are combining ABX + Copper you need heavy agitation at the surface of the water. This can be best achieved by running a powerhead aimed upward at the surface. I also run air stone and HOB filter. The combination of these meds will deplete the water column of oxygen at a heavy rate so you have to compensate. Keep in mind ABX are slow to work on fish. They are likely to be even slower in the presence of copper due to the weakened immune system. So the Spectogram IME has always prevented infection from worsening. Some have healed. I do also keep Sulfaplex and Neoplex handy for certain types of infections. They are safe to use with copper. After 14 days of therapeutic copper I transfer to a 2nd sterile QT. Temp/salinity matching. After the transfer if I have a fish that is still showing signs of infection I would run a 14 day course of NFG. If no signs of infection is present I would skip NFG. Last step is two rounds of Praziquantel using either GC or Prazipro. I prefer GC as it contains metronidazole as well and covers a few other diseases like Brook and uronema. This treatment is dosed into the water column to treat externally, as I have covered internal issues during copper with the food soaked meds. 14 Days of observation post medications prior to transfer to DT in order to make sure the fish are healthy and disease free. This is a very aggressive approach. I can tell you though I have improved my success rate significantly since adapting to this method. It is not bulletproof. The bottom line is you may have to changeup in the middle of the process due to unforeseen circumstances. After the Hanna checker discovery I was getting fish through copper without much issue, but using the same tank and treating for 30 days I was losing fish in the 20-30 day range to bacterial infection. So now using multiple tanks and reducing the copper exposure time along with having the proper ABX to be used with/without copper it is what worked best for me. We are still working on tweaking it a bit. Most of this system was designed/adapted with much help of @Humblefish + @4FordFamily. To keep up with the unfortunate condition we have recently been receiving it may have to be altered as time passes. I also preform FW dips if I see a fish scratching in copper (After 7 days at the therapeutic level) to check for flukes and/or provide temporary relief. If a fish arrives with velvet/velvet symptoms they get a FW dip as well as a 90 min Ruby Reef rally bath per @Humblefish's normal protocol. Fish with suspected ammonia burn would receive a 30 min bath in Methalyne Blue. My Personal Medication list: Copper Power API General Cure NFG http://store.nationalfishpharm.com/NFP-products-Nitrofuracin-Green-59584.Item.html Spectrogram http://www.americanaquariumproducts.com/Aquatronics.html#spectrogram Kanaplex Metroplex Neoplex Sulfaplex Furan-2 Methalyne Blue Ruby Reef Rally Formalin This is a very helpful link by @Humblefish regarding fish meds: https://www.reef2reef.com/threads/medications-to-keep-on-hand.213574/ Couple other great links regarding QT: https://www.reef2reef.com/threads/how-to-quarantine.189815/unread https://www.reef2reef.com/threads/the-dos-and-don’ts-of-quarantine.203898/unread https://www.reef2reef.com/threads/ammonia-control-in-a-hospital-tank.296119/ UPDATE: We have discovered at least one strain of velvet that survives 1.75 PPM copper, we recommend increasing to 2.0PPM to eradicate it.