Prazipro degradation

[larrysaltisfun]

Is there a time period where the fish medics believe prazi pro will be up to expected efficacy, following a previous treatment?

Said another way , regarding prazi pro degrading bacteria, is there a time period. where colonies will not rapidly degrade prazi pro following a treatment?

 

[vetteguy53081]

Is there a time period where the fish medics believe prazi pro will be up to expected efficacy, following a previous treatment?

Said another way , regarding prazi pro degrading bacteria, is there a time period. where colonies will not rapidly degrade prazi pro following a treatment?

Prazi does not have the impact such as that of copper but while it can make water cloudy does not have to do with bacteria

 

[larrysaltisfun]

Thank you for the information. I may not have worded my question properly,

what I was asking about was the efficacy of the prazipro …. because the bacteria start to consume it. I was wondering what the time period was where that bacterial degradation(.consumption) of Praze pro declines back to the point where the prazipro is fully efficacious again.

Jay Hemdal has talked about the bacterial effect on Prazipro in past posts.

 

[Jay Hemdal Verified Community Expert]

Is there a time period where the fish medics believe prazi pro will be up to expected efficacy, following a previous treatment?

Said another way , regarding prazi pro degrading bacteria, is there a time period. where colonies will not rapidly degrade prazi pro following a treatment?

It's complicated. Prazipro has praziquantel and a glycol solvent in it. Both are degraded by heterotrophic bacteria, but I'm not sure they are the same species. There is a lot of solvent in the product and that acts like carbon dosing, so you need to have good aeration when you dose it. The prazi is degraded by bacteria after some time - and that is dependent on how many doses that particular tank has received in the past. Multiple recent prazi treatments (more than 3 or 4) will render additional additions of prazi pretty much useless because it gets consumed before it has a chance to work. Some people work around this by increasing the dose (can be risky because you need to guess on how much bacteria is actually active). Other people sterilize their treatment tanks after every 5 doses of prazi.

Thread 'Dosing Praziquantel (PZQ)'

Apr 7, 2025

Using Praziquantel (PZQ) to treat flukes

Overview
In the early 1990’s, a researcher at the New York Aquarium published a paper on using Praziquantel (PZQ) to help control flukes, a parasitic flatworm. Also known as monogenean trematodes, these fish parasites can cause significant mortality in aquarium fish. It is also used orally to treat tapeworms. It has limited to no effect on other parasites. The mechanism of Praziquantel’s action seems to be that it causes the flukes to temporarily relax, allowing them to be dislodged from the fish. Once that happens, the adult fluke is...

• Jay Hemdal
• Replies: 69
• Forum: Fish Disease Treatment and Diagnosis

• 

 

[larrysaltisfun]

Is there a time period where the fish medics believe prazi pro will be up to expected efficacy, following a previous treatment?

Said another way , regarding prazi pro degrading bacteria, is there a time period. where colonies will not rapidly degrade prazi pro following a treatment?

It's complicated. Prazipro has praziquantel and a glycol solvent in it. Both are degraded by heterotrophic bacteria, but I'm not sure they are the same species. There is a lot of solvent in the product and that acts like carbon dosing, so you need to have good aeration when you dose it. The prazi is degraded by bacteria after some time - and that is dependent on how many doses that particular tank has received in the past. Multiple recent prazi treatments (more than 3 or 4) will render additional additions of prazi pretty much useless because it gets consumed before it has a chance to work. Some people work around this by increasing the dose (can be risky because you need to guess on how much bacteria is actually active). Other people sterilize their treatment tanks after every 5 doses of prazi.

Thread 'Dosing Praziquantel (PZQ)'

Apr 7, 2025

Using Praziquantel (PZQ) to treat flukes

Overview
In the early 1990’s, a researcher at the New York Aquarium published a paper on using Praziquantel (PZQ) to help control flukes, a parasitic flatworm. Also known as monogenean trematodes, these fish parasites can cause significant mortality in aquarium fish. It is also used orally to treat tapeworms. It has limited to no effect on other parasites. The mechanism of Praziquantel’s action seems to be that it causes the flukes to temporarily relax, allowing them to be dislodged from the fish. Once that happens, the adult fluke is...

• Jay Hemdal
• Replies: 69
• Forum: Fish Disease Treatment and Diagnosis

• 

So I am treating one of my display tanks. Are you then saying that after five doses it may be an indefinite time. Unless I sterilize?

 

[larrysaltisfun]

According to your thread after four months Prazipro might have its original efficacy in the same tank that it was used in the first time

 

[Jay Hemdal Verified Community Expert]

So I am treating one of my display tanks. Are you then saying that after five doses it may be an indefinite time. Unless I sterilize?

Nobody has studied how long the degrading bacteria remains active, but I know firsthand that it is longer than four months.

I should have also mentioned - when you hear about “prazi resistant flukes”, the people are actually confusing this bacterial decomposition with the flukes themselves being resistant.