Praziquantel

[Tamberav]

Years ago I had a reisstant strain of flukes and ended up dosing prazipro at 3x the recommended dose. That did clear up the flukes although I witnessed my fish 'barf' when it was first added to such a high dose. I didn't lose any fish to the prazipro but I didn't have anything particularly sensitive. My only wrasse was a yellow coris.

I have used this at normal dose in the DT without losses but noticed I had to retreat more often. Makes sense now after reading that article. Thanks for that link.

 

[Fishnut]

That appears to be brown stringy poop. If it's not white in color it may very well just be an irritated digestive system. What do you feed?

I feed: LRS fish and reef frenzy, fresh clam, pe mysis, nori, Hikari mega angel, and marine A , New Life Spectrum marine formula and some PE Flake. The poop was white and stringy and after two weeks of treatment with Metro it turned into tan in color stringy as in the photo. Most of the poop is encapsulated. The fish has put on weight and acts normal but until it is able to have a normal poop it will not make it to the display tank. Any help on treating this fish would be greatly appreciated.

 

[HotRocks]

This Sticky (Original Post) has been edited with new info. Reflecting up to date procedures and currently available products etc.

 

[LeprechaunReefer]

So from the original post, I'm gathering you can soak prazi into pellets much the same way you can soak metro - so long as you use focus to bind. My question is, I've got liquid prazi, powdered focus and good pellets to use for this (have already had success binding metro with focus the same way). When you soak 1/8 tsp prazi into pellets using focus, what dosing instructions do you follow when feeding your fish these pellets for the medication to be effective. I'm currently planning to do Prazi while also feeding the metro soaked pellets, but need to know how frequently to do it.

 

[Thomashtom]

Don’t know exactly how much prazi but tried it many times but fish got the most part won’t eat it supposedly from the taste of the prazipro. I even added garlic extreme!!!

 

[LeprechaunReefer]

Don’t know exactly how much prazi but tried it many times but fish got the most part won’t eat it supposedly from the taste of the prazipro. I even added garlic extreme!!!

I've already got them eating it, but only once. Don't want to OD!

 

[Thomashtom]

Gotcha, sorry no idea. Try Humblefish. Thanks

 

[Breadman03]

The directions for Prazipro say to stop UV during treatment. Can the UV be used to eliminate residual Prazi after treatment is complete as activated carbon would? Thanks!

 

[mjt82]

Question: When soaking food in GC (per Humblefish's recipe mentioned in the first post) is the Focus absolutely necessary? I have some Focus on order, but hoped to begin treatment with GC as soon as possible. Should I wait on it to come in before I begin treating my fish? The fish in question is a copperband butterfly that I've had for about 9 months, eats like a horse but is looking thin.

Second question: Since I'm really only concerned that one of my fish may have an internal parasite infestation - Should I be concerned that the rest of my fish will consume the GC-treated food? Is it OK for the general population whilst I'm treated the one affected fish?

 

[Big G]

As long as it is eating, go ahead and just dose into the water of the QT. Dose, Then wait 5-7 days. Do a 25% water change. Do second dose. Then wait 5-7 days. Do a 25% water change. Then observe for 10-14 days. Sometimes a second regimen is needed.

 

[mfollen]

Are there any potential issues that can occur from dosing Vibrant (cultured bacteria blend & amoino acids) while treating Prazipro in the display?

Thank you!

 

[Mjrenz]

Are there any potential issues that can occur from dosing Vibrant (cultured bacteria blend & amoino acids) while treating Prazipro in the display?

Thank you!

I would advise against it, each product has its own risks and could potentially have negative effects. I've used both, but not together, and my main concern would be with corals; prazi reduces oxygen in the water and can cause stress to corals but they usually bounce back ok, vibrant can impact the zooxanthellae in coral and also cause stress

 

[mfollen]

I'm 4 days in on the first dose in the display. Did a water change today to prepare for dose #2.

I did see a new fluke that did not die from the original dose on one of my fish yesterday. I assume this was in the egg during the first dose. It is no longer on the fish today.

Seeing as this fluke could be completing its life cycle, should this change when I dose the second dose of prazi in my display?

Questions below to ensure these flukes are eradicated:
Does this unkilled fluke change the timeline on the second dose?
Should I wait till 7 days after the original dose for dose 2? Or should I apply the second dose tomorrow, 5 days after the original?
And should I apply a third dose to ensure any remaining flukes are gone?

Thank you so much!

 

[Mjrenz]

I'm 4 days in on the first dose in the display. Did a water change today to prepare for dose #2.

I did see a new fluke that did not die from the original dose on one of my fish yesterday. I assume this was in the egg during the first dose. It is no longer on the fish today.

Seeing as this fluke could be completing its life cycle, should this change when I dose the second dose of prazi in my display?

Questions below to ensure these flukes are eradicated:
Does this unkilled fluke change the timeline on the second dose?
Should I wait till 7 days after the original dose for dose 2? Or should I apply the second dose tomorrow, 5 days after the original?
And should I apply a third dose to ensure any remaining flukes are gone?

Thank you so much!

It was most likely a hatchling, 5 to 7 days is the recommended time line between doses so tomorrow should be fine. It would be advisable to do a freshwater dip 5 to 7 days after the second dose, if you find flukes again then you've got a prazi resistant strain and another treatment would be needed (fenbendazole or hyposalinity)

 

[Kyle Bruin]

@Humblefish when soaking food in General Cure how often should I feed them that medicated food? Once then again in 7 days? or every day for 2-3 weeks?

 

[HotRocks]

@Humblefish when soaking food in General Cure how often should I feed them that medicated food? Once then again in 7 days? or every day for 2-3 weeks?

Every day for 14 days minimum.

 

[Kyle Bruin]

Interesting. Just so I can square that in my brain. I know the major benefit of food soaking the GC is that it is more reef safe that way. But feeding them that medication every day for 2-3 weeks vs emptying a packet once a week for two weeks seem like very different dosages. I would think the food method is giving the fish far more medicine. Is that true? Why would dosing the water once kill them vs just eating the food once? At least for prazi. Even dosing metroplex into the water is every 48. I would have thought the water method would have to be done more frequently than if they inject it directly.

 

[HotRocks]

Interesting. Just so I can square that in my brain. I know the major benefit of food soaking the GC is that it is more reef safe that way. But feeding them that medication every day for 2-3 weeks vs emptying a packet once a week for two weeks seem like very different dosages. I would think the food method is giving the fish far more medicine. Is that true? Why would dosing the water once kill them vs just eating the food once? At least for prazi. Even dosing metroplex into the water is every 48. I would have thought the water method would have to be done more frequently than if they inject it directly.

The two different methods of delivery treat for different ailments.

Used through food treats for internal pathogens such as worms and parasites that are in the intestinal tract.

Used through dosing the water column you are treating for external worms such as flukes. It can also be beneficial for treatment of uronema or brook since the medication contains metronidazole. You would have to dose additional metro between the GC doses to be more effective.

 

[Kyle Bruin]

The two different methods of delivery treat for different ailments.

Used through food treats for internal pathogens such as worms and parasites that are in the intestinal tract.

Used through dosing the water column you are treating for external worms such as flukes. It can also be beneficial for treatment of uronema or brook since the medication contains metronidazole. You would have to dose additional metro between the GC doses to be more effective.

Gotcha, I just reread the OP for this thread (as well as Humblefish's Internal Pathogens and Flukes posts and see the distinction now. Thanks!

 

[skijumpersc]

I have a 70 gallon tank with a 20 gallon sump that i'm afraid I'm going to have to dose with prazipro. I found what appears to be a skin fluke on my yellow watchman goby. I'm trying to catch him to do a dip and confirm, but since my reef has been contaminated I think I'm going to treat with prazipro just to be safe.

I've been reading through a bunch of threads on this and I think I have the method figured out.

1: large water change prior to treatment. 20-25%?
2: turn off carbon reactor
3:remove skimmer cup, but let skimmer run to aerate tank
4:power head or return pump at surface for more aeration
5:dose
6: 20-25% water change 7 days after dosing
8: second dose 8 days later based on marine parasite calculator
9: water change and media back online after 24-48 hours

The problem is I'm leaving for several days two days after the second dose if I do the first dose tomorrow. I'll probably have to do my water change after the second dose 24 hrs apart. That should be a sufficient time for the second dose to take effect.

Does this plan look right?